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10 Best Retinol and Hyaluronic Acid Serums for Every Skin Type

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Either you want to quench dry skin, plump wrinkles, or fight acne, retinol, and hyaluronic acid (HA) make a fabulous combo that is worthy of your attention. Using retinol and hyaluronic acid together is one of the best things you can do for your skin, regardless of skin type or age. If you want your complexion to stay smooth, moisturized and all round lovelier-looking a serum with retinol and hyaluronic acid is totally for you!


If there’s one ingredient known to help fight wrinkles, acne, and dark spots, that’s definitely retinol. Retinol is a form of vitamin A with a massive regenerative power for the skin. A strong multitasker, retinol is a potent antioxidant that fights environmental aggressors that lead to premature skin aging. Retinol is also effective at stimulating collagen production, which, in turn, smoothes fine lines and improves skin tone. The small molecular structure gives retinol the ability to penetrate deep enough into the skin layers, where it stimulates cell renewal. This is why it’s great for acne scars too! All in all, retinol-treated skin it’s modified at a cellular level; it not just looks younger, it is younger. This is possible because the small molecular weight of retinol allows it to go beneath the epidermis and do its magic.

Related: 12 Best Retinol Serums To Have In Your Anti-Aging Routine


“I tell patients it’s a great product that increases cell turnover; it shreds the unhealthy layers of skin, boosting collagen production and promoting healthy, shiny skin. In the process, you get fine lines improvement, and it helps with acne and pigmented spots,” is what Dr. Smita Ramanadham says in an interview for the American Society for Plastic Surgeons.

Hyaluronic acid

One of the world’s finest humectants (attract and retain water), hyaluronic acid is needed to keep the skin hydrated. All skin types need hydration, no exception. When layered, hyaluronic acid acts like a sponge that pulls in water to quench and plump the skin. “As a dermatologist, I love that hyaluronic acid is a lightweight, yet powerful humectant,” says Dr. Ellen Marmur, a board-certified dermatologist and founder of Marmur Medical in NYC, for Good Housekeeping. “It’s one of the most logical and healthy ingredients for providing your skin with humidity and moisture.”

Related: 9 Best Hyaluronic Acid Serums to Diminish Fine Lines & Wrinkles

The primary function of HA is to retain moisture for keeping tissues well lubricated. Hence, when we think that the main cause of skin irritation caused by retinol is lack of moisture, we have the answer for the why should I use hyaluronic acid with retinol question.

Why use retinol with hyaluronic acid?

It’s not a myth that retinol can cause skin dryness or irritation. This is why it’s better to use it every other day at first until the skin builds tolerance. In fact, retinol might cause irritations because the skin is not moisturized enough. But here’s where hyaluronic acid comes to help.

“Retinol is an incredible tool to speed up cellular turnover smooth skin and boosts collagen, while hyaluronic acid helps draw water into the skin providing a plump, glowing complexion,” says Arielle Panarello, medical aesthetician at Union Square Laser Dermatology in New York City, for TheHealthy. “You can counteract some of the dryness while still letting the retinol penetrate the outer layer of the skin. I conclude that using hyaluronic acid with retinol, it’s hydrating, soothing, and does not stand in the way of retinol’s ability to do its job.”


Reminder: Use retinol products at night because of the risk of irritation and wear sunscreen during the day, as retinoids increase skin’s sensitivity to sunlight. This rule stays still, even if you use products that contain retinol and hyaluronic acid.

The best serums with hyaluronic acid and retinol

Why use two separate products when you can use a powerful serum with both? Below are the best serums with retinol and hyaluronic acid.

best Murad serum

Murad Retinol Youth Renewal Serum

This potent serum has it all: fast-acting retinol, time-release retinol, and a retinol booster, plus hyaluronic acid to minimize dryness and boost moisture retention. It’s a solid anti-aging serum that promises to plump fine lines, correct uneven texture, and restore skin radiance in just two weeks, as the brand claims. Murad products never disappointed us, and I’m sure you’ll love this serum that’s also infused with ceramide, squalane, amino acids, shea butter, and a mix of botanical extracts to support skin resilience. Add it to your PM beauty regimen to wake up with firm and even skin each morning.

The Inkey List Retinol Anti-Aging Serum

The Inkey List Retinol Anti-Aging Serum

This serum offers a slowly released powerful retinol to boost cell turnover, promoting smoother skin without the risk of irritations. It’s a gentle gel-like serum that’s great even for sensitive skin since it’s cleanly formulated, without fragrances or alcohol. The Inkey List Anti-Aging serum pampers your skin with squalane, hyaluronic acid, peptide, and soybean extract to soothe, calm, and hydrate, making it one of the best retinol serums with hyaluronic acid out there.

Neutrogena Rapid Wrinkle Repair Serum

Neutrogena Rapid Wrinkle Repair Serum

Neutrogena serum combines retinol with hyaluronic acid in a silky formula that aims to smooth fine lines, improve skin texture and brighten. It absorbs super fast and instantly plumps the look of wrinkles and diminish age spots appearance. It is that mild retinol product your skin needs if you’re a retinol starter — start using it twice weekly until your skin builds tolerance to minimize the risk of irritations.

Yeouth Retinol Serum with Hyaluronic Acid

Yeouth Retinol Serum with Hyaluronic Acid

Yeouth’s serum comes with a retinol and hyaluronic acid formula to firm the skin and boost collagen production. The addition of aloe leaf juice, and vitamin E help protect the skin against free radicals and hydrate it intensely while speeding up skin healing. You get an antioxidant, fine lines reducer, pore tightener, moisturizer, and skin repairer in one serum! You simply can’t go wrong with this one. 

Simplified Skin Hyaluronic Acid & Retinol Serum

Simplified Skin Hyaluronic Acid and Retinol Serum

Retinol, hyaluronic acid, vitamin E, aloe vera, jojoba oil, and green tea — it sounds like a powerful cocktail for mature skin, doesn’t it? This serum aims to smooth and refine skin texture, replenish moisture levels, soothe redness and minimize the look of aging signs, like fine lines and dark spots. And it does everything at a super affordable price.

Eva Naturals Serum with Vitamin C

Eva Naturals Retinol and Hyaluronic Acid

This product is truly amazing! Loaded with vitamin C, hyaluronic acid, retinol, niacinamide, salicylic acid, squalane, and tea tree, this serum might be your skin-saving hero product. It’s not wrong to say it holds everything you need for supporting healthy skin. It’s a great dark spot corrector, acne treatment, and above all, it has great skin rejuvenation effects. Browse through all the 36,000 positive reviews if you’re not convinced yet.

InstaSkinCare Serum for Face

InstaSkinCare Serum for Face 

Most people who used this serum bragged about it and no wonder why. It’s skin-friendly, with ingredients that aim to repair and protect the skin, such as retinol, hyaluronic acid, vitamin E, and aloe vera leaf juice. With a lightweight texture, it gets fast absorbed into the skin, leaving it instantly hydrated and soothed.

Face Serum with Retinol and Hyaluronic Acid by Dermedicine Store

Dermedicine Face Serum with Retinol and Hyaluronic Acid

Formulated with retinol and hyaluronic acid, this serum promotes better skin, supported by vitamin C, collagen, ceramides, and niacinamide addition. With regular use, it improves skin’s overall look and reduces fine lines appearance, for smoother-looking skin. After 4-6 weeks of daily use, most people observed a brighter-looking glowing complexion along with skin that appears plumper and feels more supple, so we believe it worths a shot.

Bella Beauty Anti-Aging Hyaluronic Acid and Retinol Serum

Bella Beauty Anti-Aging Hyaluronic Acid and Retinol Serum

If you’re looking to hold on skin moisture naturally, this is it. Ecco Bella Beauty Store’s anti-aging serum is crafted with 98% natural and 72% organic ingredients. It’s a rich blend of retinol, hyaluronic acid, vitamin E, jojoba oil, horsetail, dandelion and green tea extracts so that your skin will feel hydrated, plumped, and protected every time you apply it. People with acne-prone skin claim that this product diminished their acne and acne scars, so you’re good to go with it if this is your case.

ZONE – 365 Facial Serum

ZONE – 365 Facial Serum

An advanced formula, all-natural for firmer skin and plumped effect, Zone-365 created a serum for multiple skin concerns, such as fine lines, aging spots, and dark spots. It does wonders for all skin types, since it fusions hyaluronic acid, retinol, vitamins C and E, plus a mix of aloe vera, orange essential oil, and vitamin B5. Plumping effect? Checked. Deep moisture? Checked. Brightener skin? Checked. You’re good to go with it!

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