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Could Resveratrol and Retinol Used Together Be A Game-Changer?

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How satisfying to write about two of my absolute favorite skincare ingredients in one post, aka resveratrol vs retinol. I love retinol serums as much as I do resveratrol, either in a glass or in skincare. Even if I’ve always taken a simple approach to my beauty regimen, I constantly keep these two heroes close. Separately, they are indeed two powerhouses, great for all skin types, but can you use resveratrol with retinol?

Resveratrol vs retinol

Resveratrol is a powerful antioxidant skin needs to stay shielded so that free radicals don’t wreak havoc on the skin. But its strengths don’t stop here. Resveratrol improves cellular function, calms skin, soothes inflammation, brightens and hydrates. How could anybody not love it? On top of everything, resveratrol penetrates the skin, going deep in the tissue layers to do its magic. It’s the fitting addition to your skin protection arsenal.

On the other hand, retinol is a vitamin A derivative that increases cell turnover, helping prevent wrinkles and diminish dark spots. While it exfoliates, its tiny molecules go beneath the epidermis where stimulates collagen production. The result? Plump, smooth, clear, and wrinkle-free skin. The right way to target skin repair.  


Can you use resveratrol with retinol?

Yes, you can use resveratrol with retinol, making your skin seal myriad benefits of protection and repair. As the skincare loyal that you are, you know during the day, the skin needs antioxidants for prevention and, at night, repairing ingredients. So it makes total sense to say use resveratrol in your AM routine and leave the retinol for the night. As you may have guessed, the best way to use resveratrol with retinol is in your nighty regimen. This is only because using retinol during the day is a no-no since it makes the skin sensitive to sunlight. 

You probably may believe the skin doesn’t need antioxidants at night as it doesn’t have to fight free radicals. Let me stop you right there. At night, you can enjoy even more of resveratrol’s perks. When wearing antioxidants during the day, the truth is that they get destroyed by free radicals while fighting to save your skin. So they don’t really get absorbed into cells where they’re needed. It’s at night when the skin has the time to supercharge from antioxidants and get in all the good they have to offer, prepping it for another day.

You know how irritating retinol can be. Pairing resveratrol with retinol helps diminish the potentially irritating effects. This is because resveratrol has anti-inflammatory properties that help minimize redness and peeling. This is great news for those with easily reactive skin. 

David McDaniel, M.D., a dermatologist in Virginia Beach, Virginia, specializing in antioxidants and anti-aging medicine, said via Vogue, “We can combine fairly potent retinoids with these [resveratrol] antioxidants for enhanced anti-aging benefits, and also avoid most of the irritation typical of vitamin A creams.”

The verdict

All in all, if you want to use resveratrol with retinol, do it at night. It’s a powerful skincare cocktail that’ll make your skin loving you back — and it does all the work while you sleep.


  1. Retinol and Vitamin C Together: Yes or No?
  2. Retinol Alternatives When You Can’t Tolerate Retinol
  3. Niacinamide and Retinol Together: Does it Work?
  4. How To Use Glycolic Acid and Retinol Together for Skincare
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