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Betaine Salicylate for Skin: How’s Different from Salicylic Acid

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Have you read about betaine in skincare, and something called betaine salicylate popped up that has awakened your thirst for knowledge? Or are you searching for a gentle alternative to salicylic acid?

Whatever your answer is, you should get familiar with betaine salicylate and its differences from salicylic acid.

Because yes, there’s a strong connection between betaine salicylate and salicylic acid, and you are just about to find out more about it. 


So in today’s article, the focus stays on betaine salicylate vs. salicylic acid and which one is more worthy for your skincare routine.

What is betaine salicylate?

As the name suggests, betaine salicylate results from the combination of salicylic acid and betaine. To recap, salicylic acid is an exfoliant often used to treat acne and reduce excess sebum, while betaine is a humectant whose role is to keep skin hydrated and plump.

In other words, betaine salicylate is a keratolytic agent (exfoliant), similar to salicylic acid but more gentle and moisturizing. 

Ok, so what’s the purpose of betaine salicylate for skin? Simply put, to counteract the salicylic acid side effects. 

Since the exfoliating power of salicylic acid may feel too harsh and cause irritations in some people, the soothing properties of betaine may help reduce those outcomes. In fact, betaine salicylate counts as an alternative to salicylic acid, especially for people who can’t tolerate salicylic acid. 

Betaine salicylate is also often used in product formulation in countries where regulations prohibit the usages of salicylic acid or where pure salicylic acid can be only used in small concentrations.


What are the skin benefits of betaine salicylate?

The skin benefits of betaine salicylate are mainly associated with the antimicrobial and exfoliant properties of salicylic acid combined with the soothing and moisturizing effects of betaine.

As such, betaine salicylate provides mild exfoliation that helps remove dead cells from the uppermost skin layer, unclogging pores and reducing breakouts appearance. So betaine salicylate mimics all the salicylic acid effects like exfoliation and antimicrobial properties, but gentler. 

Given the above, betaine salicylate may be useful for treating mild acne, reducing excess oil, and preventing future breakouts thanks to its keratolytic and pore-clearing abilities.

However, there’s a big hole in the research going into the skin benefits of betaine salicylate. That is, there’s no actual study or scientific evidence to support the benefits of betaine salicylate for the skin. Similarly, there’s no research comparing the effects of betaine salicylate to those of salicylic acid in exfoliating the skin or clearing acne.

Although betaine salicylate in skincare looks promising, there’s a lot of misinformation regarding its effectiveness. Due to the lack of evidence, there’s hard to say whether or not betaine salicylate is as effective as salicylic acid or gentler than salicylic acid.

Betaine salicylate vs salicylic acid

Unlike salicylic acid, betaine salicylate is believed to be mild on the skin. More precisely, betaine salicylate is assumed to be twice as gentle as salicylic acid but also less effective at exfoliating and clearing acne. It seems that 4% betaine salicylate is equivalent to 2% salicylic acid, but again, there’s no actual evidence to support any of these assumptions.

Side effects of betaine salicylate

Even though betaine salicylate is tender, it may cause the same adverse effects as salicylic acid, specifically dryness, irritations, and sensitivities. Yet, betaine salicylate is considered safe and suitable for most skin types unless your skin doesn’t have a hypersensitivity to it. 


Last but not least, if your skin is very dry, problematic, or your skin barrier is compromised, you should use betaine salicylate with caution. That’d mean to perform a test patch before and start with slow concentrations of betaine salicylate and gradually increase it as the skin builds tolerance.

How to use betaine salicylate

The best way to use betaine salicylate in skincare mostly depends on the product at hand. Toners, cleansers, and moisturizers containing betaine salicylate can be used twice daily, while peeling solutions must not be used more than twice weekly. Always make sure your skin is properly moisturized after exfoliating with betaine salicylate.

Is betaine salicylate good for the skin?

Despite the lack of research, betaine salicylate is definitely good for the skin. Both ingredients used in the formulation of betaine salicylate, namely betaine and salicylic acid, have well-established skin benefits and work great together to keep the skin healthy.

Can you use betaine salicylate with salicylic acid?

There’s no point in using salicylic acid and betaine salicylate together. If you do so, you risk irritating your skin badly, and the benefits you’d get from combining salicylic acid and betaine salicylate will be more or less the same than using these two ingredients separately.

Which one should you use?

Some people who’ve tried betaine salicylate and salicylic acid claimed that betaine salicylate worked better for them due to increased tolerability, while others haven’t seen much results by using it. 

So which one you should use between betaine salicylate and salicylic acid mostly depends on your skin condition and how it reacts to them. If your skin can stand salicylic acid without complications, you should keep up with it. Otherwise, betaine salicylate might be better.

Best betaine salicylate products

Although the research going into the skin benefits of betaine salicylate is far from conclusive, there are quite a few products containing it. Whether your skin can’t tolerate salicylic acid or your country prohibits it, these betaine salicylate products might be the alternatives you are looking for.

Best betaine salicylate product

Biossance Squalane + BHA Pore-Minimizing Toner

If your goal is to minimize the appearance of large pores or to enhance skin texture, this Biossance’s toner got you covered. It’s formulated with betaine salicylate to exfoliate old cells, willow bark extract to shrink pores look, and squalane to soften the skin. For sure it’s a cult favorite, and your skin will most likely love it.

Purito BHA Dead Skin Moisture Gel

Purito BHA Dead Skin Moisture Gel

Purito made a peeling gel-like solution combining betaine salicylate with the well-established tea tree extract. This duo does wonders at reducing excess oil, fighting dullness, and preventing breakouts. It does not dry out the skin (thanks to sodium hyaluronate) and absorbs really quickly.

COSRX BHA 4% Blackhead Power Liquid

COSRX BHA 4% Blackhead Liquid

To remove blackheads, use this exfoliant by COSRX. Willow bark extract, betaine salicylate, niacinamide, vitamin B5, and sodium hyaluronate work together to keep your skin in its prime condition. It contains 4% betaine salicylate, which in theory is the same as 2% salicylic acid. At this concentration, rest assured that’ll make blackheads just a bad memory.

Dr. Jart+ Peeling Essence

Dr. Jart+ Dermask Ultra Jet Peeling Peeling Essence

A blend of fruit acids mixed with betaine salicylate helps to resurface the skin and even out its tone, while olive and castor seed oils soothe skin inflammation, relieve dryness and promote good skin health.

Cos De BAHA S2 Salicylic Acid BHA 2% Liquid

Cos De BAHA S2 BHA 2% Liquid

For only $15, you get an acne spot treatment using 2% salicylic acid with betaine salicylate that’ll get clear, smooth skin without breakouts of any kind. You’d thought that such a potent formula would mess up with your skin, but it actually doesn’t, thanks to niacinamide, aloe vera, and green tea extract, which soothes and hydrate the skin.

Glow Recipe Watermelon Glow PHA +BHA Toner

Glow Recipe Watermelon Glow Toner

Enriched with betaine salicylate, hyaluronic acid, willow bark, and tea tree extracts, plus hibiscus, licorice, and sugarcane, this toner promises to hydrate the skin while minimizing the appearance of pores and dullness.

COSRX AC Collection Lightweight Soothing Moisturizer

COSRX AC Collection Lightweight Soothing Moisturizer

There’s so much to tell about this soothing moisturizer. First, it contains a lot of skin-loving ingredients such as betaine, aloe vera, glycerin, green tea, niacinamide, plus the three major compounds of Centella asiatica, asiaticoside, asiatic acid, madecassic acid. Their purpose is to keep your skin plumped, counteract dryness, reduce irritations and accelerate the skin healing process. Finally, betaine salicylate and tea tree oil ensure your skin won’t break out again.

  1. National Center for Biotechnology Information (2021). PubChem Compound Summary for CID 71587021, Betaine salicylate. Retrieved November 23, 2021.
  2. Merinville, E., Laloeuf, A., Moran, G., Jalby, .O. and Rawlings, A.V. (2009), Exfoliation for sensitive skin with neutralized salicylic acid?. International Journal of Cosmetic Science, 31: 243-244.
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