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12 Best Perricone MD Products You Need To Try Out in 2021

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As a long-standing brand in the science-backed skincare industry, Perricone MD is as coveted as ever. The American mid-range brand leads the way to moisturizers, serums, and all things skincare for more than two decades. It makes it tough to know where to start with so many products, so I’ve selected and reviewed the best Perricone MD products to build your skincare routine around. But before discovering their iconic items, let’s learn a bit about the Perricone MD brand.

Perricone MD was founded in 1997 by board-certified dermatologist Dr. Nicholas Perricone, being one of the first doctor-launched skincare brands. Still to this day, Perricone MD uses powerful clinical skincare formulations to create effective, high-quality, and pampering products. Every item of Perricone MD is made with rich formulations that target various skin concerns, with a focus on aging signs.

Their philosophy is based on the belief that beauty comes from the inside out and vice versa. This means that what we feed our bodies with and what we apply on the skin directly impact one another. For this reason, Perricone MD delivers from nutritional supplements to skincare solutions and even skincare-infused makeup products.

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Besides working at skincare formulations, Dr. Perricone had written a few books that teach people how to take care of their skin from the inside out, expressing his vision about the correlation between aging and a healthy lifestyle. Briefly, he believes the way to keep wrinkles at bay is to have a healthy diet, intake supplements, and use potent skincare solutions backed by powerful ingredients. Speaking of, these are the ingredients that you’ll most likely find in Perricone MD’s products.

Common ingredients in Perricone MD products

  1. DMAE – 2-dimethylaminoethanol is a vitamin B derivative known to have anti-inflammatory effects and increase skin firmness.
  2. Alpha-lipoic acid – it’s an enzyme that has high antioxidant activity.
  3. Copper – helps reduce fine lines look by increasing collagen proteins, evens skin tone, and has antioxidant effects.
  4. Magnesium – protects the skin against external damage by regulating cells regenerations and increasing skin recovery.
  5. Zinc – has astringent and antiseptic effects, balances oil, boosts collagen, and evens dark spots.
  6. Vitamin C Esters – L-ascorbic acid plus palmitic acid, a palm oil-derived fatty acid. This addition makes the molecule fat-soluble so it can penetrate the skin easier where it boosts collagen production, inhibits melanin production, helping lighten dark spots and even out skin tone.
  7. Hyaluronic acid – helps skin retain moisture, creates a plumping effect, and speeds up wound healing.
  8. Neuropeptides – help strengthen the skin barrier, improves skin elasticity, eases inflammation, and aid in clearing breakouts
  9. Squalane – an emollient that locks moisture into the skin, diminishing wrinkles look, has anti-inflammatory properties, and regulates sebum production

And in case you wonder, yes, Perricone MD is cruelty-free, standing against animal testing. None of their ingredients, formulations, or products are tested on animals, nor do they outsource animal testing to third parties for testing on their behalf. 

The best Perricone MD products

If you’ve decided to give this brand a shot, here are the best Perricone MD products you have to try in 2021. They won’t disappoint you!


Best Perricone MD Cleanser

Perricone MD Nutritive Cleanser

Use this Perricone MD Nutritive Cleanser to start your skincare routine. It’s a delicate gel that transforms into a foamy lather once activated with water to remove impurities build-up, pollution, and debris without drying the skin. What makes this cleanser one of the best Perricone MD products? It’s infused with alpha-lipoic acid, brightening citric acid, and a mix of magnesium, zinc, copper to nourish and strengthen the skin. No surprise it’s rated with five stars out of five on Amazon.


Best Perricone MD Toner

Perricone MD Pore Minimizing Toner

This toner is for you if you’ve got oily skin and struggle with excess sebum, breakouts, and large pores. It absorbs excess oil, exfoliates gently, diminishes pores look by cleansing them in-depth, and leaves a matte finish. All this is possible thanks to salicylic acid and zinc in its formula. More than that, it’s made with DMAE, a derivative of B vitamin, known to improve skin firmness, plus a magnesium and copper complex that boosts skin elasticity and hydrates it.


Best Perricone MD Serum

Perricone MD Firming & Lifting Serum

All skin types can use this Perricone MD serum which aids in lifting and firming the skin. It does all that by combining the trifecta of powerful skincare science, aka polyamine growth factor, eggshell membrane, and encapsulated retinol. These ingredients are well known for improving elasticity, replenish moisture and accelerate skin renewal. On top of that, it’s packed with niacinamide and antioxidant sources to keep skin protected against environmental damage. 


Perricone MD Cold Plasma Advanced Serum Concentrate

Perricone MD Cold Plasma Advanced Serum Concentrate

Perricone MD Cold Plasma Advanced Serum Concentrate performs excellently at tackling aging signs. It does everything from improving fine lines, and wrinkles look, brightening skin, minimizing pores appearance, and keeping a dull look at bay. This one traps moisture into the skin and nourishes it with a mix of peptideshyaluronic acid, a blend of botanical oils, and omegas 3, 6, and 9. This Perricone MD lightweight moisturizer also contains glycolic acid and vitamin C, making it great at fading discoloration and evening skin tone.


Perricone MD Eye Lift Serum

Perricone MD Eye Lift Serum

This serum is by far one of the best Perricone MD products for the eye area. It’s an intensive concentrate formula that addresses advanced aging signs around the eyes, targeting loss of firmness, puffiness, and dark circles with key ingredients, such as olive-derived squalane, DMAE, peptides, hyaluronic acid, and fruits extracts. The hydrating effect is instant, and the eye area feels plumper and brightener in the long term.


Perricone MD Vitamin C Brightening Complex

Perricone MD Vitamin C Brightening Complex

If discolorations and dark spots are your concerns, then you need to try this serum. It uses a ton of brightening ingredients, among which vitamin C ester, which is more easily absorbed than regular vit C, plus other two sources of this vitamin to boost the brightening and collagen-making effects. The formula is enhanced with ferulic acid that reduces fine lines look and protects against free radicals damage. With regular use of Perricone MD serum, dark spots, loss of elasticity, and dullness won’t be a problem anymore.


Perricone MD Face Firming Moisturizer

Perricone MD Face Firming Moisturizer

This Perricone MD moisturizer works wonders at plumping and firming the skin, addressing dry and mature skin types. The combination of alpha-lipoic acids, DMAE, vitamin C ester, wheat protein, and nut oil in this lightweight face moisturizer is ideal for dryness, fine lines, wrinkles, and dullness. All these ingredients work together to support skin firmness, deliver instant hydration, leaving a healthier complexion over time. Oh, and you’ll love its rose scent and the velvety finish that it leaves.


Perricone MD Neuropeptide Night Cream

Perricone MD Neuropeptide Night Cream

I know this night cream is on the pricier side, but it worths every penny, especially if you have visible aging signs. This Perricone MD product contains a mix of peptides, squalane, DMEA, hyaluronic acid, ceramides, vitamin C, and shea butter act to hydrate and repair the skin while you sleep, so you wake up with happy, nourished skin. Give it a try and you’ll thank me later!


Perricone MD Prebiotic Acne Therapy

Perricone MD Prebiotic Acne Therapy

Hey acne sufferers, this one is for you! This Perricone MD trio includes a cleanser, a day hydrator, and a night treatment, all targeting excess sebum, inflammation, and acne-causing bacteria. They are enriched with salicylic acid, ance-prone skin types BFF, aiming to decongest pores and minimize breakouts. The day step is filled with squalane to nourish, and lactic acid to gentle encourage cell renewal, while the night step is infused with niacinamide, retinol, and vitamin C, that work to heal blemishes while you sleep without drying the skin.


Perricone MD Brightening Moisturizer SPF 30

Perricone MD Vitamin C Ester Brightening Moisturizer SPF 30

Wheater you need a moisturizer, brightening cream, or SPF protection, this Perricone MD’s product got you covered. Its brightening and smoothing effects are given by vitamin C, while alpha-lipoic acid increases antioxidants defense against environmental aggressors, and mineral-based zinc oxide delivers SPF protection. This moisturizer is lightweight, oil-free, suitable for all skin types, and without any trace of SLS or parabens, being one of the best Perricone MD products at the moment.


Perricone MD Overnight Intensive Firming Mask

Perricone MD Overnight Intensive Firming Mask

This intensive mask aims to repair the skin, so you wake up with minimized fine lines and firm skin. It uses restorative ingredients like squalane, DMEA, vitamin C, shea butter, and a blend of natural oils to boost the skin’s natural regeneration process, hydrate, and soothe. The addition of thioctic acid to the formula helps promote collagen production, plumping fine lines and wrinkles, and has anti-inflammatory benefits — what you need to tout young-looking skin.


Perricone MD Neuropeptide Facial Conformer

Perricone MD Neuropeptide Facial Conformer

Launched in 2003, this lightweight serum is called liquid gold and is Perricone MD’s best-seller product for a reason. I won’t pretend it’s not super expensive, but if you’re planning to splurge on a skincare product that tackles skin discoloration, advanced photodamage, and dull skin, this is it. It does everything helped by vitamin C, a fusion of peptides, ceramides, oat proteins, and green bean seed extract, each moisturizing, boosting collagen, and strengthening the skin. 


Perricone MD Serum Foundation

Perricone MD Serum Foundation

If you want a foundation that improves skin, feels like a serum, and has a semi-matte finish, look no further. Perricone MD serum foundation smooths everything, from fine lines to scars, while protects against sunbeams with SPF 20 with zinc oxide — you still need that sunscreen underneath, though. This foundation corrects and camouflages uneven tone instantly, and you won’t even feel like wearing it. The thing is, it’s available only in seven shades, making it difficult to find the right match for everyone. 


Perricone MD Mascara

Perricone MD Mascara

Another one of the best Perricone MD makeup products is this 2-in-1 mascara and lash treatment. One stroke and lashes appear lifted and thicker, and at the same time, it nourishes and conditions them, so your lashes strengthen in time. It’s made with candelilla and carnauba waxes, avocado oil, peptide, nettle extract, and biotin to condition your lashes with each application. It may not have the blackest black, but it’s a great multitasker.


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