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9 Best Adenosine Creams You Should Try In 2022

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Adenosine is definitely a skin-loving ingredient welcome in any cream. Not only it has well-established soothing and anti-inflammatory properties, but it can also soften wrinkles and accelerate the skin-renewing process thanks to its ability to stimulate collagen synthesis.[1][2]

Due to these distinctive benefits, adenosine became one of the most popular ingredients in skincare products targeting skin repair, aging marks, compromised barrier, as well as irritated and rough skin.

If your natural thirst for knowledge asks for more, you can read everything about adenosine in skincare here

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To be noted, adenosine can only be used in concentrations of up to 1% in skincare products, which is why you’ll not find it at the top of the ingredients labels. Don’t freak out. You’ll still get all the benefits from adenosine at this concentration.

The best adenosine creams

Now that you know the drill, below are the best adenosine creams that’ll keep your skin soft and healthy.  


StriVectin Rich Barrier Cream

StriVectin Rich Barrier Cream

This adenosine-infused cream is one of the StriVectin most-loved products for skin repair and wrinkles reduction. It’s working like a charm at replenishing the skin, smoothing rough patches, and increasing hydration, thanks to five types of ceramides, fatty acids, and cholesterol — the three essential lipids that make up the skin’s barrier. In addition, the cream contains adenosine and a unique property form of niacinamide to maintain skin integrity and calm irritations, resulting in fewer wrinkles and more glow. Dryness, sensitive skin, redness, and the lack of radiance will be things of the past after using StriVectin Rich Barrier Cream.


Peter Thomas Roth Hungarian Thermal Water Moisturizer

Peter Thomas Roth Hungarian Thermal Water Moisturizer

Here we’ve got another winner. Peter Thomas Roth Hungarian Thermal Water is one of the best adenosine creams you’ll find on the market simply because it has adenosine among the first in the ingredients list. It’s just right after ceramide, retinyl palmitate (a form of vitamin A), vitamin E, ascorbyl palmitate (a form of vitamin C), and glycerin. The best part about this formula is its base, Hungarian thermal water, which is rich in minerals, having calming and anti-inflammatory effects on the skin. You can count on this cream to hydrate, plump, protect, and firm your complexion.


SkinCeuticals Triple Lipid Restore

SkinCeuticals Triple Lipid Restore

Whether it’s about reliving dehydrated skin, softening irritations, enhancing radiance, or renewing the skin, SkinCeuticals Triple Lipid Restore gets the job done. The secret? It is formulated with the three essential skin lipids: ceramides, cholesterol, and fatty acids working to restore the skin’s natural barrier. In turn, this reduces the apparition of wrinkles, increases moisture, and consolidates the skin’s defense against external aggressors. Thanks to its soothing and repairing benefits, it’s one of the best creams to use after a chemical peel, sunburn, or intense dryness. And without question, it’s one of the best adenosine creams.


La Roche-Posay Redermic R Retinol Cream

La Roche-Posay Redermic R Retinol Cream

If you prefer lightweight gel-like formulas, take a look at La Roche-Posay Redermic R Retinol Cream. The cream combines the skin-renewing properties of retinol and lipo-hydroxy acid (a derivate of salicylic acid) with the moisturizing benefits of glycerin in a thermal water base to promote healthy and radiant skin. There’s also adenosine, which supports skin repairing and alleviates irritations, while sodium hyaluronate ensures the skin won’t overdry. This formula aims to improve skin texture and keep aging signs at bay and works terrific for mature, dry, and sensitive skin. However, oily skin should avoid this cream as it contains some oils that can clog the pores.


Dr. Dennis Gross Anti-Aging Moisturizer

Dr. Dennis Gross Ferulic And Retinol Anti-Aging Moisturizer

This moisturizer comes as one of the best adenosine-infused creams for anti-aging. Buckle up because there is quite a bit to unpack here. Dr. Dennis Gross Ferulic + Retinol is not only packed with potent anti-agers such as retinol and peptides but also with antioxidants (ferulic and gallic acids, tocopherol), exfoliants (lactic and glycolic acids), anti-irritants (adenosine, cica), and hydrators (amino acids, sodium hyaluronate, and glycerin). There’s nothing this cream can’t do in terms of aging signs: wrinkles, fine lines, dullness, lack of firmness, and dark spots will no longer be a problem. 


Paula's Choice Resist Intensive Repair Cream

Paula’s Choice Resist Intensive Repair Cream

Another cream containing adenosine that our team swears by is Paula’s Choice Resist Intensive Repair. Since it’s infused with skin-restoring ingredients such as niacinamide, ceramide, peptides, and adenosine, plus essential fatty acids, sodium hyaluronate, and green tea, the cream promises to restore and re-plump even the most dehydrated and cracked skin. In the meanwhile, retinol accelerates cell turnover, improves skin texture, and enhances firmness, revealing a more radiant and vibrant complexion. As for the end, its lightweight creamy formula makes it to most people’s liking, especially since it doesn’t leave the skin feeling greasy.


Kate Somerville DeliKate Recovery Cream

Kate Somerville DeliKate Recovery Cream

You literally can’t go wrong with Kate Somerville DeliKate Recovery Cream. It’s a cream formulated for all skin types, including even the most problematic ones, working to comfort, relieve, and replenish the skin until it gets to its best condition.

It does that thanks to its antioxidant-rich formula enriched with softening and moisturizing ingredients coming from natural extracts, namely green tea, soybean seed, rosemary, and ginger extracts. Other skin-loving ingredients include adenosine, a peptide complex, three types of ceramide, cholesterol, and tocopherol. The cream’s role is simple: to calm stressed skin, reduce redness, itchiness, and relieve dryness. It’s fragrance- and alcohol-free, so this moisturizer actually nourishes your skin, not messing with it.

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best Centella asiatica cream

Dr. Jart+ Cicapair Cream

Everyone who loves Centella asiatica, aka cica, should try Dr. Jart+ Cicapair Cream. It not only contains cica but also its main bioactive compounds, asiaticoside, madecassoside, asiatic acid, and madecassic acid, known to have soothing and repairing benefits for the skin. There’s also niacinamide, vitamin E, green tea, adenosine, glycerin, sodium hyaluronate, and ceramides making it one of the best adenosine creams out there. 


The Body Shop Drops of Youth Cream

The Body Shop Drops of Youth Cream

If you are looking for the best adenosine cream for oily skin, this is it. The Body Shop Drops of Youth Cream combines the exfoliating and pore-clearing abilities of salicylic acid, with antioxidants from caffeine and tocopherol, plus the moisturizing and relieving properties of adenosine and glycerin to reveal that bouncy and dewy complexion you’ve always wanted. Since it’s non-comedogenic, the cream fits oily skin like a glove, but it’s not suitable for sensitive and dry skin types since it contains alcohol among the first in the ingredients list, which could feel very icky and drying. It never hurts to do a patch test before, though.

References
  1. Perez-Aso M, Fernandez P, Mediero A, Chan ES, Cronstein BN. Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3FASEB J. 2014;28(2):802-812. doi:10.1096/fj.13-241646
  2. Haskó G, Cronstein B. Regulation of inflammation by adenosineFront Immunol. 2013;4:85. Published 2013 Apr 8. doi:10.3389/fimmu.2013.00085
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