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Top 10 Peptide Serums Really Good for Your Skin

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Peptides are one element that totally worth the hype! Using a serum that contains peptides can help make your skin look firmer, hydrated younger, with fewer breakouts, can repair damaged skin, even out skin tone, and ease inflammation. A promising skincare ingredient, it seems that everybody needs peptides in their skincare routine. 

For starters: what peptides do

First, some background. Naturally occurring in the skin, peptides are required for making proteins in our skin, helping to keep a better skin condition and play a key role in all manner of biological activity. In skincare products, peptides can come from natural sources (plants, fish, eggs), but they can also be created synthetically. There’s a bunch of peptides, all with different powers. Each type of peptide is designed to take care of different skincare tasks, like improving hydration or skin tone, firming skin, or even creating new fibroblasts or collagen.

Peptides act as building blocks of proteins, having a role in supporting your skin to stay firm, soothed, and hydrated. They penetrate deeply into the skin, providing access to other ingredients. When two amino acids are joined by a single bond, it’s called a dipeptide. Three linked amino acids form a tripeptide, followed by tetrapeptides, and so on; you got it. Peptides can typically contain 50 or fewer amino acids. Simply put, peptides are amino acids that make up some proteins needed by the skin, such as collagen, elastin, and keratin. Peptides can even control factors that contribute to skin sensitivity, tone, and hormonal activity (acne). No doubt, peptides are highly beneficial for all skin types.


The exciting thing about peptides is that they can penetrate the outer skin layer — they’re called messengers for the other skin cells for some reason. Sinking deep into the skin layer, they naturally support key cellular functions to build or repair skin cells. 

Despite their formulations’ complexity, peptides won’t produce any irritation, inflammations, or allergic reactions. Actually, they work wonders when paired with a few active ingredients without losing their potencies, such as niacinamidehyaluronic acidantioxidantsvitamin C, and retinol. At the same time, I wouldn’t recommend peptides with AHAs (due to the acidic pH) — do the peeling prior to using your peptide serum.

10 Best Peptide Serums for Aging Skin

Now that you’ve got your background around peptides, scroll on to shop ten of the best peptide serums for all your skincare needs.

ELEMIS Peptide Antioxidant Serum

1. ELEMIS Peptide4 Antioxidant Hydra-Serum

Dehydrated, tired-looking skin? Not a problem anymore with this serum. Enhanced with peptides to support and replenish the skin, saffron and lotus flower milk (rich in flavonoids and polyphenols) that’ll leave your skin softened and brightened. Plus, the low molecular weight hyaluronic acid supports skin’s moisture barrier — a great addition to your routine in one step! Elemis Hydra Serum delivers a boost of antioxidants and hydration while defends the skin against environmental damage.

PCA SKIN Total Strength Serum

2. PCA SKIN Total Strength Serum

You can lift, firm, and smooth aging skin with this peptide and growth factor serum that fights wrinkles and minimizes pores’ appearance. With antioxidants from milk thistle and sodium hyaluronate added to its formula, it keeps your skin protected against free radicals and deeply moisturized all day long, without any clammy, sticky, or oily feeling. Also, it contains tea tree oil, making it great if your complexion tends to breakout sometimes.

Korres Golden Krocus Elixir

3. Korres Golden Krocus Elixir

Besides copper peptides, amino acids, beta-glucans, and a whole of botanical extracts, this skincare elixir contains krocus flower extract — which blooms once a year in Greece — restoring your skin to its best condition. It even inlcudes lactic acid, which helps with exfoliation, revealing brightened skin. The copper peptides work to boost collagen and elastin production, resulting in plumper, smoother skin. And there’s more: this serum is 94.9% natural!

Microderm Peptide Complex Serum

4. Peptide Complex Serum by Microderm

Many people call this serum magic in a bottle. Probably because it’s infused with natural skin-loving ingredients for healthy, hydrated, and plump skin: three types of peptides, hyaluronic acid, Japanese green tea, aloe vera, cucumber extract, and honeysuckle, to name a few. It naturally boosts the skin’s collagen production, promoting youthful-looking skin, reduces dark spots and blemishes at once.

ISDIN Peptide Serum Ampoules

5. ISDIN Peptide Serum Ampoules

Ampoules regularly have more active ingredients than serums, so imagine how powerful this is. Two types of hyaluronic acid (low and medium molecular weight), HydraFilm, which reinforces the hydrating ability of HA, and SoothCalm — peptide with calming properties to reduce the feeling of dry skin. With a lightweight consistency, it quickly boosts moisture in your skin, which feels even 72 hours after.

The Ordinary Buffet + Copper Peptides

6. The Ordinary Buffet + Copper Peptides

Targeting aging signs, this serum uses a combination of ingredients, including 1% copper peptides, which have a role in improving textural damage and even out your skin tone. Along with this, a mix of age-defying peptides, a probiotic complex, vitamin C, 11 amino acids, and hyaluronic acid boost to leave your skin as healthy as possible. The total concentration of active ingredients in its formula is 26.1% — pretty powerful.

Babor Ampoule Serum Concentrates

7. Babor Ampoule Serum Concentrates

For a concentrated skincare booster for dull skin in need of radiance and moisture, try Babor’s peptide ampoules. Highly concentrated, these ampoules are charged with a serum enriched with peptides, cacao extract to help protect against blue-light aging, sugar beet extract to combat oxidative stress, and keep your skin moisturized. Also, it’s made with glow pigments to even out your skin tone and leave your complexion radiant and fresh-looking!

Peter Thomas Roth Peptide Serum

8. Peter Thomas Roth Peptide and Neuropeptides Serum

Are you ready for a game-changing skincare serum that restores your skins’ youthful elasticity and firmness? 73% peptide and neuropeptide complex, hyaluronic acid, squalane, proteins, and vitamins A, C, and E will do the job in keeping your skin hydrated, moisturized while improving its texture. It does come with a higher price tag attached, but it’s a great option if you want to fight aging signs.

Eminence Skincare Peptide Serum

9. Eminence Organic Skincare Marine Flower Peptide

Are you an organic skincare lover? Then Eminence Peptide Serum will suit you best! Three times an award winner, it visibly reduces the appearance of wrinkles and dehydrated skin with its strong formula, which features a blend of natural nourishing extracts, including botanical hyaluronic acid, phyto collagen, and peptides sourced from rice protein. With a gel-serum-like texture, it feels lightweight while it’s easily absorbed into the skin for a more youthful-looking appearance. So clean, so nourishing!

Paula's Choice Peptide Booster

10. Paula’s Choice Peptide Booster Serum

Winner of Total Beauty Award Editor’s Pick Best Serum

A truly peptide-booster, this serum has in its formula eight types of peptides that target wrinkles, discoloration, and loss of firmness. The addition of hydrating amino acids complex and repairing ingredients help restore and fortify your skin, improving its texture while diminishing fine lines’ appearance. The silky, lightweight gel absorbs instantly, and you can use it alone or add a few drops to your moisturizer to intensify its effects. We love it!

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