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Adenosine in Skincare: What Is It, How to Use, and Products

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Adenosine might not be the most popular ingredient at the moment, but it’s definitely a promising one, and I believe it’s about to become the next skin-soothing hero. I’ve heard many rumors about adenosine lately, so after a quick research on what topical adenosine can do, I found out that adenosine in skincare is a thing for a while now. It has a few benefits for the skin, and it’s safe for all skin types. After reading this post, you’ll know what can adenosine in skincare do and if it worths all the fuzz.

What is adenosine

By its very nature, adenosine is present in the body as part of a molecule called adenosine triphosphate that helps transfer energy for some of the cellular and muscular functions throughout the body. In layman’s terms, adenosine has a cell-signaling role in the body, which makes it an important compound.

In skincare formulations, adenosine is a water-soluble white, odorless, crystalline powder derived from yeast. Yes, this means adenosine is a natural ingredient that all skin types can use.

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What adenosine does in skincare?

Adenosine has proved multiple benefits in skincare, and a few studies were conducted regarding its potency, mostly in anti-aging. 

The Expert Panel for Cosmetic Ingredient Safety concluded that adenosine could be used in concentrations of up to 1% for skincare products. For this reason, you’ll most likely notice adenosine by the end of the ingredients list. Yet, the skin gets enough benefits when slathered in a product with adenosine. According to an NFSA risk profile, a cream containing low adenosine concentrations gets absorbed into the skin at a maximum of 2%

Anti-aging benefits

The anti-aging benefits of adenosine are the most discussed, and there are a few reasons topical adenosine improves fine lines and wrinkles. This study conducted by the International Journal of Cosmetic Science revealed that adenosine has beneficial effects on crow’s feet and forehead wrinkles after applying a cream with adenosine twice daily for two months to 84 women. A reasonable explanation for adenosine’s effects on smoothing fine lines and wrinkles comes from its ability to stimulate collagen synthesis. This is possible because adenosine binds to fibroblasts’ cells receptors, responsible for synthesizing collagen. Collagen has a massive role in keeping the skin elastic, firm, and plump, so any ingredient that boosts collagen is welcome, especially when its natural production starts to decrease after the age of 25. For this reason, you’ll most likely see adenosine in moisturizers for mature skin

Soothing properties

Adenosine has been found to have anti-inflammatory properties as it inhibits the neutrophil cells’ inflammatory actions. So, since it regulates inflammatory cells’ function, you’ll see adenosine in products meant to soothe and heal burns or cuts. Adenosine aids in reducing irritations, making it a great candidate for easily reacting skin.

Healing effects

Since adenosine helps stimulate collagen production, it encourages the skin to repair faster, has restorative effects upon wounds and broken tissue, and strengthens the protective barrier. Collagen is vital for wounds healing as it’s that protein that gives the skin firmness, structure, and strength. 

Who can use adenosine

All skin types can benefit from adenosine. It doesn’t target a specific skin type or concern. However, since it acts as a collagen-booster and due to its anti-inflammatory properties, adenosine is primarily used in anti-aging skincare routines. This skin-soothing powerhouse is also a great bet for those who have a broken skin barrier.

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Side effects

As I mentioned already, adenosine is a compound that occurs naturally, so the chances to irritate or cause sensitivity to the skin are null. The only exception is if you have a known allergy to it. 

Best adenosine skincare products


anti aging cream l'occitane

L’Occitane Immortelle Divine Cream

This is definitely something you’d want in your anti-aging routine. L’Occitane’s best-selling cream targets wrinkles, fine lines, and uneven skin texture with a mix of natural extracts and skin-soothing ingredients such as adenosine, camelia sativa oil, and hyaluronic acid. It’s lightweight and gentle, so most skin types can use it, making it one of the best adenosine creams out there!


Vichy Idealia Moisturizer

Vichy Idéalia Smooth & Glow Energizing Moisturizer

If your skin is normal or mixt, you can use this one as your day cream. Vichy uses adenosine, black tea, and blueberry to boost the skin with antioxidants and energized it for stressful days and pollution. With a gel-cream texture, it leaves a velvety smooth touch, the perfect canvas for makeup too!


Paula's Choice Omega+ Complex Eye Cream

Paula’s Choice Omega+ Complex Eye Cream

For a quick pick-me-up for your eye area, this cream stands out. Besides skin-restoring adenosine, it uses omegas, antioxidants, ceramides, niacinamide, squalane, hyaluronic acid, and a blend of botanical oils to hydrate, protect, minimize the look of crow’s feet, and brighten the skin.


Dr. Dennis Gross Stress Repair Face Cream

Dr. Dennis Gross Stress Repair Face Cream

Or you can try this non-comedogenic and nutrient-rich face cream that helps prevent and correct signs of aging with niacinamide, adenosine, avocado, squalane, hyaluronic acid, and other fruit extracts. It keeps the skin moisturized and nourished while supports skin barrier defense. Dr. Dennis Gross Face Cream works for all skin types, including dry, oily, and sensitive skin, being one of the best adenosine products.


La Roche-Posay Pure Retinol Face Serum 

La Roche-Posay Pure Retinol Face Serum 

For an adenosine-boosted serum that targets aging signs, this might be the best bet. La Roche Posay formulated a serum that combines the most effective ingredients for fine lines, wrinkles, and dark spots, aka retinol, adenosine, vitamin B5, niacinamide, hyaluronic acid, and vitamin C. Make it your next PM skin-repairing serum.


SkinCeuticals Triple Lipid Restore

SkinCeuticals Triple Lipid Restore

A cult-favorite for those who want to tackle aging signs, SkinCeuticals Triple Lipid Restore is one of the best corrective creams out there. Adenosine, ceramides, natural cholesterol, fatty acids, essential oils, and vitamin E are just a few of the ingredients that accelerate hydration, boost barrier function, improve elasticity and firmness of the skin.


L'Occitane Anti-Aging Face Serum

L’Occitane Immortelle Divine Serum

L’Occitane Immortelle Divine Serum is here to help you get a wrinkle-free complexion with their in-house Immortelle extract, a gentle alternative of retinol, adenosine, and a complex of botanical extracts and oils. This serum is as organic and clean as possible, so it’s ideal for you whenever you have sensitive or easily reactive skin. 

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