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Procapil for Hair Growth: Everything You Need to Know

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We all live with the impression that shampoos and serums can help us regrow our hair, and it is still us who get disappointed after realizing that this is not true. Even American Hair Loss Association claims that 99% of all products that address hair loss are completely ineffective.

This is very worrying if you consider that over 12 million Americans used hair regrowth products only in the last year. Because cosmetics don’t require FDA approval to be marketed, every product’s effectiveness is questionable. Brands are also allowed to make unrealistic claims, which rarely turn out to be true.

No one can tell you if a product really works or not. So what do you do? It’s simple! Check the product label and look for active ingredients that have been scientifically proven to stop hair loss and promote its growth — like Procapil. If you spot that ingredient, you are ready to go. Here’s why.

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What is Procapil?

Procapil is a breakthrough formula used in hair strengthening and anti-hair loss treatments such as shampoos, conditioners, and leave-on products. It strengthens hair and combats the hair follicle aging process, preventing premature and excessive hair loss. Procapil does all of that by targeting the leading cause of alopecia: 5a-reductase, which converts testosterone to DHT, and low blood flow in the scalp.

Procapil was formulated with three plant-derived substances with different mechanisms to help follicles produce healthier hair. Oleanolic acid is used to inhibit 5a-reductase and reduce DHT conversion, apigenin to enhance the scalp blood circulation, and finally, glycine–histidine–lysine peptides bounded to vitamin H (Biotinyl-GHK) are used to meet the hair follicle metabolic needs. Don’t panic; you’ll get soon what all that means.

Procapil formula may sound confusing, but it is really not hard to understand each compound’s role. Continue reading to understand how Procapil stimulates hair growth and helps you achieve better hair. 

How does Procapil stimulate hair growth? 

It targets DHT conversion

The first target of Procapil is obviously androgenic alopecia, the most common form of hair loss caused by androgens, more precisely a testosterone derivative called dihydrotestosterone (DHT). You know that hair follicles are the ones responsible for the production of hair strands, right? Well, to actually grow hair, follicles undergo repetitive cycles of regeneration. If the hair follicles are damaged or weakened, they are likely to produce less and weaker hair. The same may happen when the hair growth cycle is disturbed.

Apart from nutritional deficiency and thyroid disease, research found that elevated DHT levels in the body are one of the main reasons for weakening the hair follicles. DHT is converted from testosterone by particular enzymes called 5-alpha reductase (5-AR). Procapil, with the help of oleanolic acid (extracted from olive leaves), inhibits 5-alpha reductase enzymes to stop testosterone conversion to DHT.

The use of a 5-alpha reductase inhibitor has been shown to reduce hair loss in people presenting with a markedly receded hairline. A 47% increase in hair in the growing phase was obtained after one year through the simple inhibition of 5-alpha reductase. 

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It boosts scalp blood flow

Another hair growth mechanism of Procapil is working as a vasodilator, thanks to apigenin — a citrus extract flavonoid with a vasodilatory effect. Vasodilators are medications that open blood vessels, and their role is to increase blood flow in the body to tissues that need it most.

Basically, Procapil helps increase scalp blood flow. That way, it allows inactive follicles to reconnect with dermal papillae, structures located under the follicle that produce the hair shaft. Once the hair follicle is reconnected to the dermal papillae, it’s likely to start to grow healthy hair. This is also exactly how Minoxidil works, as it’s a vasodilator too. 

It delays hair follicles aging

The last compound, Biotinyl-GHK, a vitamin-carrying peptide formed from biotin (vitamin H), was added to Procapil’s formula due to its anti-aging activity. This study suggests that Biotinyl-GHK holds dual matricial and metabolic action, meaning that it ensures a better ‘rooting’ of the hair in the scalp and an enhanced adhesion between dermal papilla and hair follicle. It’s believed that improved interfacing would positively impact the quality and duration of the hair growing phase.

Similarly, enhanced anchorage should delay the beginning of the telogen phase (resting phase). Since studies found that biotin deficiency leads to thin hair, alopecia, loose skin, and dermatitis, it’s obvious why you need it. One report determined that out of 466 women (aged between 9–92 years), biotin deficiency was found in 38% of those who suffered from hair loss. 

Long story short, Procapil has anti-androgenic proprieties (as Finasteride), vasodilatory effects (as Minoxidil), and anti-aging activities. You see now why Procapil is so good to stimulate hair growth? It practically does everything for your hair to grow healthy and strong. 

What studies say about Procapil?

Unfortunately, compared to Minoxidil or Finasteride, Procapil lacks scientific evidence that proves its mechanisms in stimulating hair growth. Or better said, there’s not enough data to draw a conclusion.

Few clinical trials for Procapil exist, but they are under the same study case. In a four-month trial, 35 men aged between 18-50 years suffering from hair loss were treated with 3% Procapil twice daily. By the end of the trial, people presented +10% more hairs in the anagen phase. The same study concluded that Procapil in 4 months works better than Finasteride in 5 months. While the existing research may not be enough, we can’t deny the fact that Procapil has potent properties to enhance hair follicles. Each compound plays its own role essential for healthy hair growth. 

Procapil side effects

As Procapil is pure botanical, it’s believed to have no side effects. However, there’s literally no data about the side effects of Procapil, thus we can’t validate it. We always recommend consulting a doctor every time you want to start a new treatment.

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Procapil products

You can find Procapil under different concentrations (1%, 3%) in shampoos, serums, leave-on products, usually addressing hair growth. Here is what we like the most:

The Ordinary Hair Growth Serum

The Ordinary Hair Growth Serum

How can you not like The Ordinary when they’ve got so many excellent products? Take this hair growth serum, for example. It’s not that it just contains Procapil, but it’s enriched with extremely powerful ingredients like RedensylCapixyl, and even caffeine. For real, these are the pillars of every great product to increase the hair density. 

Grande Cosmetics Hair Enhancing Serum

Grande Cosmetics Hair Serum

Formulated with vitamins, peptides, and amino acids, this hair-enhancing serum by Grande Cosmetics supports healthier and thicker hair while improving its overall condition. And guess what? Besides Procapil, it’s formulated with Ginkgo Biloba and flower extracts that are known to help stop hair loss. Do you need more?

Procapil vs minoxidil

According to one research, 1% Procapil was 58% more effective than minoxidil, while 2.5% Procapil shows 121% more hair growth. Similarly, minoxidil maintains hair follicles’ proliferative activity, as does biotinyl-GHK. However, as much as we want to believe Procapil is better than minoxidil, more studies are needed to make a call. After all, minoxidil is approved by the FDA and has more studies and evidence than Procapil supporting its role in hair growth. 


Read more:

  1. 12 Organic Shampoos & Conditioners for Hair Growth
  2. 8 Best Castor Oils for Hair Growth & Scalp Conditioning
  3. 7 Things to Avoid If You Want to Stop Hair Loss in Women
  4. 9 Best Redensyl Products for Hair Loss
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